I'm taking 150mg of diclofenac a day for PA until my Enbrel starts to work. I'll be taking my first shot on Thursday.
My dr. prescribed 100mg of the slow release at bedtime to help me sleep. It usually helps enough to sleep and then have enough left over in the morning so my poor wife doesn't have to dress me.
He also prescribed 50mg diclofenac SOD so when the slow release wears off I can take that.
My question; the diclofenac can take hours to kick in. If I take it a 6AM it'll start providing relief between 11 and noon. Is this normal for diclofenac? The slow release can take a long time as well. (I'm also doing hep-c tx)
I have been taking diclofenac for years now, varying between 100mg, to 150mg a day. There have also been times where I have had to temporarily stop taking it when I had a stomach flu and the Dr. prescribed something for the flu that conflicted with the diclofenac. What I can tell you from this is that diclofenac builds up in the body system over time and the longer you stay on the medication the better it works. If you stop taking it, even temporarily, it once again takes some time before it builds up enough in the body system to work at its most effective. But once it has built up in the body you can reduce your dosage and still receive the bets effects from the medication. I can also tell you that if you have to take cholesterol lowering medication as well, like I do, the dosage of these two different medications will cause liver problems if not monitored carefully. For instance: the most effective dosage of diclofenac for me is 75mg twice a day, and the most effective dosage of cholesterol lowering medication is 20mg of Zocor. But the two in combination always raises my hepatitis B liver count to unhealthy levels. So currently I am working with my Dr. to try and find a combination of the two meds that works, yet doesn't raise my liver count.
DCT
"Puckertoe" <puckertoe@@don;tspamme.com> wrote in message news:12629do5vc6fm36@corp.supernews.com...> Greetings,>
I'm taking 150mg of diclofenac a day for PA until my Enbrel starts to > work. I'll be taking my first shot on Thursday.>
My dr. prescribed 100mg of the slow release at bedtime to help me sleep. > It usually helps enough to sleep and then have enough left over in the > morning so my poor wife doesn't have to dress me.>
He also prescribed 50mg diclofenac SOD so when the slow release wears off > I can take that.>
My question; the diclofenac can take hours to kick in. If I take it a 6AM > it'll start providing relief between 11 and noon. Is this normal for > diclofenac? The slow release can take a long time as well. (I'm also doing > hep-c tx)>
It usually starts to kick in at about one hour for me and is really having an effect at 90-120 minutes - I take only the standard stuff, twice/day. But...... everyone's different. The 50 mg tabs definitely aren't slow-release as well? You might let your doc know it's taking it do long to kick in. He might be able to give you something else to take during the day.
-- Nann remove the Gator cheer to email me Simply the thing I am shall make me live --- William Shakespeare
snip >I can also tell you that if you have to take cholesterol> lowering medication as well, like I do, the dosage of these two different > medications will cause liver problems if not monitored carefully. For > instance: the most effective dosage of diclofenac for me is 75mg twice a > day, and the most effective dosage of cholesterol lowering medication is > 20mg of Zocor. But the two in combination always raises my hepatitis B > liver count to unhealthy levels. So currently I am working with my Dr. to > try and find a combination of the two meds that works, yet doesn't raise > my liver count.>
I've been taking 3 x 50mg of Diclofenac Sodium for years now. Once or twice I've stopped taking it for various reasons. Within a couple of days I can hardly walk.
I'm four weeks into taking a 10mg daily dose of statins tablets for high cholesterol. No side effects yet, but I don't know what the symptoms are for "unhealthy levels". Could you tell me, or won't I know util the moment I collapse lol
"Splodge" <sport.last@ntlworld.com> wrote in message news:4cepl4F15hnvnU1@individual.net...>
snip >I can also tell you that if you have to take cholesterol>> lowering medication as well, like I do, the dosage of these two different >> medications will cause liver problems if not monitored carefully. For >> instance: the most effective dosage of diclofenac for me is 75mg twice a >> day, and the most effective dosage of cholesterol lowering medication is >> 20mg of Zocor. But the two in combination always raises my hepatitis B >> liver count to unhealthy levels. So currently I am working with my Dr. to >> try and find a combination of the two meds that works, yet doesn't raise >> my liver count.>>
I've been taking 3 x 50mg of Diclofenac Sodium for years now. Once or > twice I've stopped taking it for various reasons. Within a couple of days > I can hardly walk.>
I'm four weeks into taking a 10mg daily dose of statins tablets for high > cholesterol. No side effects yet, but I don't know what the symptoms are > for "unhealthy levels". Could you tell me, or won't I know util the moment > I collapse lol>
Splodge
No, you won't collapse or anything like that. LOL! Actually the only way to determine it is by having regular bloodwork done. I go back and have mine checked at least every six months.
I have been taking diclofenac retard for years (100 mg daily). My experience is similar to yours ie taken at breafast time, it takes around 3 hrs to show any effect. This may not be totally a drug effect. Remember that in the case of rheumatoid patients there is a natural progression thro the day, and these people are generally at their best, late morning until early afternoon. Fatigue can occur in the mid pm and maybe they feel better for a while in the evening.
Elimination half life is stated as 1.2 - 3hrs (slow release spreads the release over a longer period and the effect of a single dose is much longer than the half life) - See http://en.wikipedia.org/wiki/Diclofenac Max dose seems to be 150 mg daily, but 100 mg more usual. My own experience is that a single 100 mg retard tablet is effective for about 18 hrs. I think, also, that increasing effectiveness over several days may be due to the drug's progressive damping effect on inflammation rather than to a continual build up in the body. Blood test have always been part of my treatment. I also get occasional gut problems.
I'm taking 75 mg twice a day. Guess it's working most of the time. I take mine after breakfast and after the evening meal (supper for me!). Gwen
<diclidophora@yahoo.co.uk> wrote in message news:1147349046.351583.45410@i39g2000cwa.googlegroups.com...> Puckertoe.>
I have been taking diclofenac retard for years (100 mg daily). My> experience is similar to yours ie taken at breafast time, it takes> around 3 hrs to show any effect. This may not be totally a drug effect.> Remember that in the case of rheumatoid patients there is a natural> progression thro the day, and these people are generally at their best,> late morning until early afternoon. Fatigue can occur in the mid pm and> maybe they feel better for a while in the evening.>
Elimination half life is stated as 1.2 - 3hrs (slow release spreads the> release over a longer period and the effect of a single dose is much> longer than the half life) - See> http://en.wikipedia.org/wiki/Diclofenac> Max dose seems to be 150 mg daily, but 100 mg more usual.> My own experience is that a single 100 mg retard tablet is effective> for about 18 hrs.> I think, also, that increasing effectiveness over several days may be> due to the drug's progressive damping effect on inflammation rather> than to a continual build up in the body. Blood test have always been> part of my treatment. I also get occasional gut problems.>
I've been taking 3 x 50mg of Diclofenac Sodium for years now. Once or>> twice I've stopped taking it for various reasons. Within a couple of days >> I can hardly walk.>>
I'm four weeks into taking a 10mg daily dose of statins tablets for high >> cholesterol. No side effects yet, but I don't know what the symptoms are >> for "unhealthy levels". Could you tell me, or won't I know util the >> moment I collapse lol>>
Splodge> No, you won't collapse or anything like that. LOL! Actually the only way > to determine it is by having regular bloodwork done. I go back and have > mine checked at least every six months.
I just started taking diclofenac on 6/1/07,50mg 3x day,in less than a week i was admitted to the hospital,I thought i was dying,had a giant rock on my stomach,i am so sad,,i have arthritis so bad in my hands and the meds was actually starting within a few days to actually help.i have been on everything,but these side affects are terriable,for me anyway,it looks like the meds have worked for some of u all,I am so happy for u.does anyone one have any suggestions for me to try next without dyin in the process(lol),thanks,gloria
I 've been taking Diclofenac sod for about a year and a half. Before that I was taking Naproxin with no real relief. Sometimes for no real reason or if I let my prescription run out I miss a dose or two and then I am reminded of why I take it. I don't really know of any side effects, but if anyone does please let me know. Thanks, Bill
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