serotonin syndrome or toxic build up?

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GYXE > Anxiety > serotonin syndrome or toxic build up? 12 November 2007 04:16:01

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serotonin syndrome or toxic build up?
JimD 12 November 2007 04:16:01
	Hey group, I have been trying to wean on to an SSRI for the last 2-3 weeks and I have been having bad reactions to all of them. Over the past 10 years I have been on Zoloft and Lexapro, so I am not new to SSRI's. Anyway, about 4 weeks ago or so my managed symptoms stopped being managed and I got hit with a panic attack out of the blue. Well this led to a few bad days which caused some symptoms to return. Now when I am not feeling well from anxiety/panic/depression I don't eat much and I don't drink much. I might drink 1 glass of water a day and have a 1/4 cup of vegetarian beens or maybe just a small bowl of cereal with a little Soy milk for the whole day. Over the last 4-5 weeks, that is basically what I have done and I have lost 30+ lbs. The first two weeks of this period I stopped taking the Lexapro I was on for almost 2 years and started taking Trazodone to help a little with depression/anxiety. The last 3 weeks I have been trying to start an SSRI and it has been one nightmare after another. I first tried Paxil CR for 4 days and had bad anxiety, but I noticed I started to feel very nauseous by the second or third day. After 4 days I went to Effexor and used that for 2 days. During those 2 days I used only a small amount of Effexor and did not even have 1 full 37.5mg pill over the 2 day period. However, my body reacted very bad and I actually went to the hospital for the first time because of my anxiety/panic. I thought I was having an allergic reaction because not only was my anxiety really strong, I also had very bad nausea, racing heart, this sickening drugged up feeling, and my pupils seemed to be more dilated than normal, though they did still react to light when the doctor checked them. Since then I have tried to go back to the Lexapro that I was fine on for almost 2 years and after a week of only taking 5mg/day I had to stop because my reaction to the medication was so bad. Which doesn't seem right since I had only stopped taking it about 4 weeks ago and it didn't bother me for the previous two years. The last two days I have been trying Luvox and I am having the same problems. I feel anxiety, nausea, hot, sickening drugged up feeling, and my pupils seemed to be more dilated than normal. I was wondering if anyone has ever had a similar experience with toxic build up of SSRI metabolites or serotonin syndrome. I am just trying to figure out why my body is reacting so badly to SSRI medication I have been on for the last 10 years. I hope it is just because I am a little under nourished and dehydrated. I can fix that. Thanks for any help! JimD -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Chip 22 January 2006 08:46:59 [ permanent link ]
	"JimD" <JimDaGeek@gmail.com> wrote The first two weeks of this period I stopped taking the Lexapro I was on> for almost 2 years and started taking Trazodone to help a little with> depression/anxiety. I would have added the trazodone to the Lexapro. The Lexapro was still working, but not as effectively, so you were having breakthrough symptoms. I am just trying to figure out why my body is reacting so badly to SSRI> medication I have been on for the last 10 years. Jim, you might be having the bad reactions to the meds cause your anxiety level is so high. If you got it down with a benzo, you might be able to wean back onto an SSRI. Chip -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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JimD 22 January 2006 18:29:04 [ permanent link ]
	Chip wrote:> I would have added the trazodone to the Lexapro. The Lexapro was still> working, but not as effectively, so you were having breakthrough symptoms. This is what my pDoc said. Jim, you might be having the bad reactions to the meds cause your anxiety> level is so high. If you got it down with a benzo, you might be able to wean> back onto an SSRI. This could be true, though I have never felt so ill before. I guess I was just wondering if it is possible to have a toxic build up of SSRI metabolites if one doesn't drink/eat enough over the course of a few weeks. I forced myself to drink about 4 cups of water last night and did feel a little better. This morning I forced myself to eat finally and I had about 3 cups of water and have not taken the Luvox. I might go today and tomorrow with not taking any SSRI and eating and drinking enough to get my system feeling better. Does Ativan act on serotonin? For example does it increase or decrease levels of serotonin? I wanted to try not to take any meds for today and tomorrow that affect serotonin levels to see if I do feel better and this ill feeling goes away. Chip Thanks for the help! JimD -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Marie 22 January 2006 21:28:28 [ permanent link ]
	JimD wrote:> Hey group,> I have been trying to wean on to an SSRI for the last 2-3 weeks and I> have been having bad reactions to all of them.> The last 3 weeks I have been trying to start an SSRI and it has been one> nightmare after another. I was wondering if anyone has ever had a similar experience with toxic> build up of SSRI metabolites or serotonin syndrome. Well, I'm no doc, but apparently you and I are having trouble with SSRIs for a good reason. Personally I believe I know why I do poorly on them (hyper-adrenals) and my PDoc seems to agree. She is putting me on a regimen to stabilize my nervous system, increase stage four sleep, and do no harm to the already taxed adrenals. SSRIs (and Margrove, a PDoc, agreed) tax the adrenal glands to produce more adrenalin and cortisol, at least initially). Hence my PDoc and I are getting rid of any AD that taxes the nervous system. Your case may or may not be the same. -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Chip 23 January 2006 06:52:54 [ permanent link ]
	"JimD" <JimDaGeek@gmail.com> wrote Does Ativan act on serotonin? No. It acts on the GABA-benzodiazepine receptor complex. Chip -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Guest 24 January 2006 23:57:43 [ permanent link ]
	On Sun, 22 Jan 2006 21:52:35 -0600, JimD <JimDaGeek@gmail.com> wrote: A lot of the symptoms I had/have sound like what happens when one has excessive Serotonin levels or "Serotonin Syndrome". http://www.fpnotebook.com/PSY183.htm From everything you describe, you are suffering from the typical SSRI side-effects and "weaning on" symptoms. Serotonin syndrome is a medical emergency, it is extremely dangerous. If you had serotonin syndrome, you would be very ill. If you really feel you are suffering from this..........please notify your doctor. Really? That helps me feel better to know I am not the only one. I did a little research and it is called, Mydriasis http://www.fpnotebook.com/EYE36.htm. Yup! Here is a link to my post about it in 99. http://groups.google.com/group/alt.support.anxiety-panic/msg/33665852ff67f8d4?dmode=source * The funny thing is that as soon as I tried to start the SNRI Effexor is when the Mydriasis and other symptoms of excessive Serotonin started. I hope you are feeling better today Jackie ~~I've been on an emotional roller coaster lately. The other day my mood ring exploded~~ ~ Janine DiTullio ~ -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Marie 26 January 2006 02:50:38 [ permanent link ]
	JimD wrote: Hey group,> I have been trying to wean on to an SSRI for the last 2-3 weeks and I> have been having bad reactions to all of them. Have you done an adrenal test? I did the ASI Test which Margrove didn't particularly care for but which is showing promise and being used by more and more neuroendocrine docs. If your adenal glands are in hyper-mode (as mine are--severely), then SSRIs are going to tax them harder, giving you the tremors, shakes, nasty hypoglycemia, and the like. I went through the same thing with Lex. We're just harder cases. There are semi-anecdotal reports of people who were on SSRIs and developed adrenal exhaustion (Chronic Fatigue Syndrome) because the glands get tricked by the extra serotonin into creating more adrenalin and cortisol. Margrove here concurred. Hence the awful symptoms. Some folks here don't have it so bad. Bipolar folks have adrenal output in the mega range. Hence a serotonin booster will send them through the roof. Lots of folks here are encouraging you to "hang in there," but I have concerns that you could be damaging your body. Some nausea and stuff like that is fine, but if it gets really nasty, I would personally have major concerns. -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Chip 27 January 2006 23:22:47 [ permanent link ]
	"Marie" <anebt2@peoplepc.com> wrote SSRIs (and Margrove, a PDoc,> agreed) tax the adrenal glands to produce more adrenalin and cortisol,> at least initially). Any new med that causes uncomfortable side effects can increase the output of the adrenals. Chip -- ========== Please DELETE this text block when replying! ========== Contact the moderators at: asapm-board@stump.algebra.com The charter is available at: http://readystump.algebra.com/~asapm ========= This notice is added to each approved article ==========
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Guest 12 November 2007 04:16:01 [ permanent link ]
	what's a regimine?
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GYXE > Anxiety > serotonin syndrome or toxic build up? 12 November 2007 04:16:01

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