I can not enter my blog. Nothing works at all! What to do?
Not Us -  But Interesting
Hello Guest
  
  • Login
• Register…
• Start blog
  • Who, Where, When
• What can I do?
• What to Read?
  • Polls
• Avatars
• Interests
  • Cities and Countries
• Random blog
• Users search
  • Search
• Games
• Tests
• GYXE
  • Сообщества
• Talxy Chat
• Horoscope
• Online
 
Зарегистрируйся!

GYXE > Anxiety > Not Us - But Interesting 14 November 2005 02:38:47

  Recent blog posts: 
  Forums:   
  Discuss: 
  Recent forum topics: 
  Recent forum comments:
  Moderators:

Not Us - But Interesting

Blues Ma 14 November 2005 02:38:47
 Psychiatric disorders and immunity
Molecular self-loathing

Sep 29th 2005
From The Economist print edition
Anorexia and bulimia may be autoimmune diseases—and so may several other
psychiatric illnesses

SOMETIMES, the immune system works in mysterious ways. During an
infection one of its roles is to produce antibodies designed to attack
and eliminate the invading bugs. However, in certain unlucky individuals
the body also develops so-called autoantibodies which attack its own
tissue, sometimes with devastating effects. The result is known as an
autoimmune disease, two well-known examples of which are type-1 diabetes
and multiple sclerosis. But there is a widespread suspicion among
researchers in the field that a lot more diseases than these have an
autoimmune component. In particular, they think, a number of illnesses
usually labelled as “psychiatric” are actually, at bottom, the result of
autoimmunity.

Until now, that suspicion has been based on correlations between certain
sorts of infection and certain sets of psychiatric symptoms. But work
just published in the Proceedings of the National Academy of Sciences by
Serguei Fetissov of the Karolinska Institute in Stockholm and his
colleagues has tied the connection more tightly for two psychiatric
eating disorders—anorexi­a nervosa and bulimia nervosa.

Dr Fetissov's work suggests that abnormal levels of autoantibodies
against hormones called melanocortins are a crucial part of the cause of
these two diseases. Melanocortins are small protein molecules that carry
messages between nerve cells in the brain. They are involved in
regulating a variety of complex behaviours, including social
interactions, stress responses and—most importantly in this context—food
intake. So it is easy to see how interfering with them could cause
anorexia and bulimia.

Shooting the messenger

To test this idea, Dr Fetissov and his colleagues analysed blood serum
from three groups of women (both anorexia and bulimia are more common in
women than in men). One of these groups consisted of people diagnosed as
anorexic. The second was composed of individuals diagnosed as bulimic.
The third contained people with no eating disorder.

The researchers looked to see whether there was any relationship between
the levels of autoantibodies to melanocortins in these women and their
expression of particular psychological traits—such as “Drive for
thinness”, “Body dissatisfaction” and “Perfectionism”­вЂ”which are
associated with eating disorders and which can be measured using a
specially designed scoring system.

What they found was intriguing. There was not one relationship, but two.
The level of autoantibodies to melanocortins was positively correlated
with anorexia, but it was inversely correlated with bulimia. These
opposite correlations make sense. Although both disorders are associated
with depression and self-doubt, anorexia involves a constant refusal to
eat, whereas bulimia is a “diet-binge-purge­ disorder” that includes
periods of excessive consumption. The molecular triggers of the two
could thus easily be opposites.

The ultimate cause of the altered levels of autoantibody in anorexics
and bulimics is unresolved as yet. However, according to the
researchers, a clue may lie in the fact that micro-organisms, too, work
in mysterious ways. In the world of bacteria and viruses, a strategy
called molecular mimicry is common. In this, pathogens evolve to produce
pieces of protein similar to those of their hosts, as a way of confusing
that host's immune system. But the immune system is not always fooled,
and in making antibodies to the “camouflage” proteins it sometimes turns
out weapons that also attack the useful proteins that are being mimicked.

Two common gut bacteria, Escherichia coli and Helicobacter pylori, and
also the influenza-A virus, are particularly adept at playing the
evasive game of molecular mimicry, and the team is now looking at
possible connections between different gut bacteria and autoantibodies
against melanocortins to see if they can pin down which, if any, of
these bugs might be responsible.

That is not to say, even if Dr Fetissov's idea is correct, that
autoimmunity is the whole story. Both anorexia and bulimia are known to
go hand in glove with particular personality characteristics which are
not directly related to the disease. In anorexics, striving for
perfection and conscientiousness are common non-pathological traits. In
bulimics, such traits include risk-taking behaviour and problems with
impulse control. So there appear to be predisposing factors at work, as
well as the triggering effect of the autoantibodies.

Nevertheless, given the range of behaviours regulated by melanocortins
and other, similar, messenger molecules, the suspicions that other
psychiatric disorders—in particular, obsessive-compulsiv­e disorder—are
partly or wholly the product of a similar process seem entirely
plausible. Dr Fetissov's work also adds weight to the idea that two
other neurological diseases, schizophrenia and Tourette's syndrome, have
an autoimmune component. In the case of these diseases, the damage seems
to be caused irreversibly in the womb, suggesting that any
autoantibodies involved are attacking structural molecules rather than
messengers (attacks on structural molecules are the cause of multiple
sclerosis, though they involve a different part of the immune system).
That gives little hope for treatment. But in the case of anorexia,
bulimia and, possibly, obsessive-compulsiv­e disorder, Dr Fetissov's work
opens a new line of thinking about how these diseases might be treated. >
Add comment
Elliott 14 November 2005 02:38:47 permanent link ]
 On Sun, 13 Nov 2005 17:18:27 -0600, Blues Ma, in reality a Dr. on TV, did a
quick butt scratch, felt at one with the universe again, so decided it was time
to share the following words of wisdom with the common folk - beginning with:
Dr Fetissov's work also adds weight to the idea that two >other neurological diseases, schizophrenia and Tourette's syndrome, have >an autoimmune component. In the case of these diseases, the damage seems >to be caused irreversibly in the womb, suggesting that any >autoantibodies involved are attacking structural molecules rather than >messengers (attacks on structural molecules are the cause of multiple >sclerosis, though they involve a different part of the immune system). >That gives little hope for treatment. But in the case of anorexia, >bulimia and, possibly, obsessive-compulsiv­e disorder, Dr Fetissov's work >opens a new line of thinking about how these diseases might be treated.

Yes, I think it's interesting. The above segment brought to mind that there are
several states that now classify Panic Disorder as neurological in origin. I
find that's an accurate category for some, if not most cases of 'out of the
blue' panic that begins and keeps on going.

The resulting phobias aren't neurological, of course, but the origin?

Epilepsy was thought to be a psychiatric disorder until fairly recently, where
it clearly became neurological. I've always felt that's where the research needs
to be directed - to look into the origins of panic.

Yes, very interesting....


--
Elliott remove eee to eeemail

http://home.earthli­nk.net/~ejk2/
Add comment
 

Add new comment

As:
Login:  Password:  
 
 
  
 
Пожалуйста, относитесь к собеседникам уважительно, не используйте нецензурные слова, не злоупотребляйте заглавными буквами, не публикуйте рекламу и объявления о купле/продаже, а также материалы нарушающие сетевой этикет или УК РФ.


GYXE > Anxiety > Not Us - But Interesting 14 November 2005 02:38:47

see also:
Shepherd's Pie
Monastery
Hey guess what I just been driving…
пройди тесты:
see also:
Sale of KIDNEY
fentanyl patch
Kidney for sale by owner

  Copyright © 2001—2008 GYXE
Idea: Miсhael Monashev
Помощь и задать вопросы можно в сообществе support.gyxe.com.
Сообщения об ошибках оставляем в сообществе bugs.gyxe.com.
Предложения и комментарии пишем в сообществе suggest.gyxe.com.
Информация для родителей.
Write us at:
If you would like to report an abuse of our service, such as a spam message, please .